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Overview This trial is active, not recruiting. non-ST segment elevation acute coronary syndrome: the British Heart Foundation RITA-3 randomised trial.
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RITA-3 TRIAL; Problem: NSTEMI/UA (mod-high risk) Format: Multi-center RCT: Treatment: Angiography +- PCI within 48h: Control: Medical therapy: Population: 1810 patients: Inclusion criteria: Suspected cardiac chest pain at rest and had documented evidence of coronary artery disease with at least one of: RITA 3 is really a trial of care in a specialist centre plus intervention versus care in a district general hospital, since after randomisation the intervention group was transferred to the presumably better resourced specialist centres. 2020-05-31 2002-12-14 2002-12-14 RITA-3 is the first large-scale clinical trial designed to test an initial conservative strategy (medical therapy) versus an initial interventional strategy (angiography) in patients with unstable angina or non-ST segment elevation myocardial infarction. Recruitment for the RITA-3 trial is now complete. Next Article The RITA 3 trial Sir—Christoph Pechlaner and Christian Wiedermann take issue with the conclusion that an interventional strategy is preferable to a conservative strategy on the basis of a nominal but non-significant excess of deaths within the first year.

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The RITA-3 (Third Randomised Intervention Treatment of Angina) trial compared outcomes of a routine early invasive strategy (coronary arteriography and myocardial revascularization, as clinically indicated) to those of a selective invasive strategy (coronary arteriography for recurrent ischemia only) in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS). PCI is also beneficial in NSTEMI patients (TACTICS-TIMI-18, RITA-3). Statins reduce recurrent cardiovascular events, with a trend emerging as early as 30 days .